Research progress of circular oligonucleotides
نویسندگان
چکیده
منابع مشابه
Inhibitory properties of double-helix-forming circular oligonucleotides.
Several circular oligonucleotides were synthesized and characterized by electrospray ionization mass spectrometry. Experiments on termination of primer extension catalysed by DNA polymerases, Klenow fragment and Tth have demonstrated that a double helix forming circular 2'-deoxyribooligomer containing a 25mer sequence complementary to the target single-stranded DNA along with a 34mer random mis...
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We report the synthesis and nucleic acid binding properties of two cyclic RNA oligonucleotides designed to bind single-stranded nucleic acids by pyr.pur.pyr-type triple helix formation. The circular RNAs are 34 nucleotides in size and were cyclized using a template-directed nonenzymatic ligation. To ensure isomeric 3'-5' purity in the ligation reaction, one nucleotide at the ligation site is a ...
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Sankhapushpi (Convolvulus pluricaulis) the popular Medhya Rasayana drug of Indian medicine has been reported in the past as having significant beneficial effect in patients of anxiety neurosis and epilepsy. Sharma et al (1965) has reported that the extract of this drug reduces the spontaneous motor activity of mice, the reduction being more maked in amphetamine treated hyperactive mice. The hyp...
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ژورنال
عنوان ژورنال: SCIENTIA SINICA Chimica
سال: 2018
ISSN: 1674-7224
DOI: 10.1360/n032018-00090